Ionel I Mangalagiu
Alexandru Ioan Cuza University of Iasi, Romania
Title: Recent achivements in the chemistry of five and six member ring nitrogen heterocycles
Biography
Biography: Ionel I Mangalagiu
Abstract
During the last fifty years, nitrogen heterocycles compounds have received considerable attention as highly valuable materials in the fields of pharmacy / medicine, opto-electronics and agriculture.As part of our ongoing research in the field of azaheterocycles derivatives, we present herein some core results obtained by our group in the field of nitrogen heterocycles derivatives, focused on chemistry and their pharmacological and industrial potential applications.
The chemistry presented is straight and efficient, and focused in the area diazols, triazols, azine (and bis-azine), diazine (and bis-diazine), phenanthroline and related. Stereo- and regio- chemistry aspects are discussed. The chemistry involve both conventional (thermal heating) and nonconventional (microwave and ultrasounds) methods.Concerning pharmacological potential applications, our attention was focused in the area of obtaining compounds with anticancer, antimycobacterial, anti-leishmanial, and other antimicrobials activity.
For the industrial potential applications our research was focused in obtaining of new chemical entities with fluorescent property, molecular devices (such as logic gates), chemosensors, growth regulators for plants, pesticides and insecticides, ionic liquids for synthetic uses.