Ivanka Stankova
South-West University, Bulgaria
Title: N,N-dimethylglycine-amantadine – synthesis and biological activity (antiparkinsonian activity)
Biography
Biography: Ivanka Stankova
Abstract
NMDA receptor blockade can improve L-DOPA-induced dyskinesias in Parkinson's disease (PD) patients. Amantadine is well-tolerated and effective antiparkinsonian agent, was recently found to possess NMDA antagonistic properties. Oxidative damage, may contribute to dopaminergic neurodegeneration in the substantia nigra of patients with PD. N, N-Dimethylglycine (DMG) (also known as vitamin B15 or pangamic acid) acts as an antioxidant, extending the lifespan of animal cells through protection from oxidation. In this study we synthesized and tested in vivo the newly obtained compound N,N-Dimethylglycine-Amantadine (DMG-Am) for antiparkinsonian activity. MPTP (1-methyl -4 –phenyl-1, 2, 3, 6- tetrahydropyridine) is widely used neurotoxin as an experimental model which mimics some Parkinson‘s disease-like symptoms.