18^th European Organic Chemistry Congress July 18-19, 2022 Amsterdam, Netherlands

Biography:

Shlomo Rozen was born in Bulgaria and immigrated to Israel as a small child. He received his Ph.D. from the Hebrew University of Jerusalem and then spent 3 years in the Research Institute for Medicine and Chemistry, Cambridge, MA, under Nobel laureate D. H. R. Barton, where he began work with elemental fluorine. In 1976, he joined the School of Chemistry at the Tel Aviv University where he assumed the position of Professor of Chemistry in 1989. On multiple occasions he had held a position of visiting scientist at the Central Research Department of the DuPont Company. His main goal in chemistry is to demonstrate that elemental fluorine and reagents derived from it are very useful in general organic chemistry, as well as in fluorine chemistry and chemists should discard their unjustified fears and prejudice against this long known but somewhat neglected element.

Abstract:

Most oxidants are metal oxides such as CrO₃, KMnO₄ and alike. Compounds containing the peroxide moiety (-O-O-) serve occasionally either as oxidants or oxygen transfer agents, mainly as reagent for epoxidation of certain olefins. The problem with most orthodox oxygen transfer agents is that they are relatively weak (a weak electrophilic oxygen) and need a strong nucleophilic center in order to react successfully. The only imaginable compound with strong electrophilic oxygen is one where the oxygen is bound to an element which is more electronegative than itself and this is possible only when it is bonded with fluorine. HOF is known for more than 50 years and made by passing F2 through ice. It is very unstable and decomposes in 10 minutes even at -100^oC making it unsuitable for any synthetic purposes. When however, we passed dilute fluorine in nitrogen (about 10%) through aqueous acetonitrile an oxidative solution was obtained which proved to be the complex of HOF with CH₃CN (HOF•CH₃CN). This complex is stable at 0^oC for more than an hour allowing a wide array of chemical syntheses to be executed. This complex is able to transfer its oxygen to many substrates and produce many unknown oxides which could not be made before despite continues efforts for many years. Among these reactions we will mention phenanthroline-N,N-dioxide, perfluorinated sulfones, All-S,S-dioxo-thiophenes including their oligomers (important ingredients in electronics), epoxidation of electron poor olefins, oxidation of vicinal amines to vic-dinitro derivatives, success in making the elusive N,N-dioxopyridazine and many more. In addition, since the reacting oxygen originates from the water molecule, it is relatively simple and cheap to constructing alcohols with the isotope 

Biography:

Hendawy N. Tawfeek, Phd, was born in Minia, Egypt. Bachelor of Science, Chemistry– 1999 Faculty of science Minia university, Egypt. I have my MsC (2015) and Phd (2020) in the field of organic chemistry. I am interested in the synthesis of heterocyclic compounds, Chromatographic separation techniques. I worked at Minia university from 2000 till now. My position is the head of occupational of safety and health unit, Minia university, Minia Egypt.

Abstract:

Quinolone and their derivatives have a challenge in their use as prospective pharmacophores in the field of medicinal chemistry. The synthesis of hybrid drug takes the interest of scientists. Here our trend is to synthesize and evaluate the biological activities of four quinolone hydrazide four scaffolds of open structures and heterocycles. The structures of the synthesized compounds were determined by advanced spectroscopic tools as well as X-ray diffraction structure determination. 

Biography:

Dr Neelakshi Shaku is affiliated to Indian Institute of Technology, Kanpur. She is a recipient of many awards and grants for her valuable contributions and discoveries in major area of subject research. Her international experience includes various programs, contributions and participation in different countries for diverse fields of study. Her research interests include Protein Biochemistry, Protein Structure and Protein Chemistry.

Abstract:

The noun “bola” relates to the shape of a South American missile weapon. The simplest form of “bola” consists of two balls which are attached to both ends of a cord. The term “bolaform electrolyte” (short form: “bolyte” or “bolion”) was introduced by Fuoss and Edelson in 1951 for a chain of hydrophobic groups connecting two hydrophilic end groups. For less water-soluble analogues, the name “bolaform amphiphiles” (short form: “bolaamphiphiles”) is preferred. The biological and biochemical applications of amino acids and synthetic peptides have evolved over the years, offering an effective means to satisfy the technological demand of modern biomaterials. Design of peptide-based bolaamphiphiles offers a simple and facile means to organize peptide and amino acid motifs with the aid of nonbiological hydrophobic centers, realizing a protein-mimetic configuration at the molecular level. Inspired by these thoughts, we have synthesized a new class of amino acid based bolaamphiphilic surfactants derived from L-Lysine and L-Glutamic acid residues and have studied their applications in different fields. The results of our studies in this direction are presented in the poster.

Biography:

Dr. Parkhomenko studied chemistry at the Altai State University (chemistry faculty) in Barnaul, Russia from 2005 to 2010. In 2010 he moved to Novosibirsk to start his PhD project in the Nikolaev Institute of Inorganic Chemistry. His doctoral dissertation was conducted under the direction of Prof. I.K. Igumenov and focused on the synthesis of novel series of metal complexes with different organic ligands, the investigation of correlations between structure, morphology, composition of gold layers deposited by MOCVD and regimes of their deposition and precursor type, as well as the development of techniques for the deposition of gold nanoparticles and nanometer-sized films in different porous matrixes. After successfully defending his thesis, he started to study composite materials based on metal phthalocyanines and nanoparticles/thin metallic films as well as the surface chemistry of metal nanoparticles and their optical properties for biomedical applications, including the investigation of plasmonic nanolasers (spasers). In 2019 he joined the Nanomaterials group under the leadership of prof. M. Knez where he is currently working. He has strong collaborations with scientific groups in the USA, UK, the Netherlands, Poland, Germany, and other countries. His results were published in 20 scientific publications; his close collaborations with industry have lead to 3 patents related to technological applications of gold nanoparticles. He presented his work in 15 talks (including 2 invited) at international conferences as well as in seminars in Europe, Asia and Russia. He won several upscale grants including Russian presidential scholarship and Marie Skłodowska-Curie individual fellowship.

Abstract:

Despite numerous articles published every year on gold nanoparticles (GNP) they are still of tremendous interest due to their unique optical, catalytic, electronics properties, etc. The most recent application of gold nanoparticles is their utilization as a resonator in plasmonic nanolasers (spasers) in which GNP are surrounded by a thin layer of an active medium whose emission band overlaps with the spectrum of localized surface plasmons of the metal nanoparticle. Nowadays, the colloid spasers have been created in the form of core-shell structures in which the molecules of an active medium are placed into the mesoporous silica shell surrounding the gold core. Thus, the amount of the dye involved in the generation, and consequently the intensity of generation, is limited to the pore capacity of the silica shell. In this regard yolk-shell particles, due to the large free volume available, are considered to be an outstanding candidate for the spaser creation. Besides, the particles of such an architecture have been used as nanoreactors or biological probes for cancer detection. Here we present a novel method of producing hollow nanoparticles composed of gold nanorods core surrounded with a polymeric shell of polystyrene sulphonate. The proposed approach consists in covering the gold nanorods with silica followed by its slow hydrolysis in an aqueous media with the presence of the polymer. We showed that such particles can be filled with different organic dyes and can be used in spaser applications.

Biography:

Dr Ivanka Stankova is affiliated to South-West University. She is a recipient of many awards and grants for his/her valuable contributions and discoveries in major area of subject research. Her international experience includes various programs, contributions and participation in different countries for diverse fields of study. Her research interests include Amino Acid, Chemical Stability, Hydroxycinnamic Acid, Peptides and Thiazole Oxazole.

Abstract:

NMDA receptor blockade can improve L-DOPA-induced dyskinesias in Parkinson's disease (PD) patients. Amantadine is well-tolerated and effective antiparkinsonian agent, was recently found to possess NMDA antagonistic properties. Oxidative damage, may contribute to dopaminergic neurodegeneration in the substantia nigra of patients with PD. N, N-Dimethylglycine (DMG) (also known as vitamin B15 or pangamic acid) acts as an antioxidant, extending the lifespan of animal cells through protection from oxidation. In this study we synthesized and tested in vivo the newly obtained compound N,N-Dimethylglycine-Amantadine (DMG-Am) for antiparkinsonian activity. MPTP (1-methyl -4 –phenyl-1, 2, 3, 6- tetrahydropyridine) is widely used neurotoxin as an experimental model which mimics some Parkinson‘s disease-like symptoms.

Biography:

Dr Maya G. Chochkova is affiliated to South-West University. she is a recipient of many awards and grants for her valuable contributions and discoveries in major area of subject research. Her international experience includes various programs, contributions and participation in different countries for diverse fields of study. Her research interests include Antioxidant Activity, Antioxidant Assays, Alkaloids, Antioxidants and DPPH

Abstract:

Neurodegenerative diseases affect millions of people worldwide and are becoming more prevalent, particularly in the elderly. Amongst the neurodegenerative disorders, Alzheimer’s disease (AD) is the most common form of dementia. Since the most AD cases are known to be nongenetic, it is believed that the complex of various risk factors leading to oxidative stress, combined with the aging process may cause this illness.

Therefore, antioxidants (e.g. hydoxycinnamic acids-caffeic, ferulic and etc.) possessing the therapeutic potential to overcome the oxidative stress might reduce the risk of development of this severe pathology.